abstract：:The present study investigated the neuroprotective effects of Forsythia suspense extract in a rotenone-induced neurotoxic model. FS8, one of the herbal extracts, markedly protected PC12 cells against rotenone toxicity and was selected for the in vivo study. Gavage administration of FS8 (50 and 200mg/kg, but not 10mg/k...

journal_title：Neurotoxicology

authors： Zhang S,Shao SY,Song XY,Xia CY,Yang YN,Zhang PC,Chen NH

更新日期：2016-01-01 00:00:00

abstract：:Dopamine (DA) and serotonin (5-HT) seem to be involved in several of the effects of ethanol (EtOH). Acetaldehyde (AcH), especially in the brain, induces effects that mimic those of EtOH. The purpose of this study was to investigate the effects of local perfusion of EtOH and AcH on extracellular DA and 5-HT in the dors...

journal_title：Neurotoxicology

authors： Jamal M,Ameno K,Miki T,Tanaka N,Ito A,Ono J,Takakura A,Kumihashi M,Kinoshita H

更新日期：2016-01-01 00:00:00

abstract：:Over the past decade people have been constantly exposed to microwave radiation mainly from wireless communication devices used in day to day life. Therefore, the concerns over potential adverse effects of microwave radiation on human health are increasing. Until now no study has been proposed to investigate the under...

journal_title：Neurotoxicology

authors： Megha K,Deshmukh PS,Banerjee BD,Tripathi AK,Ahmed R,Abegaonkar MP

更新日期：2015-12-01 00:00:00

abstract：:The effects of exposure to volatile organic compounds (VOCs), which are of concern to the EPA, are poorly understood, in part because of insufficient characterization of how human exposure duration impacts VOC effects. Two inhalation studies with multiple endpoints, one acute and one subchronic, were conducted to seek...

journal_title：Neurotoxicology

authors： Kodavanti PR,Royland JE,Moore-Smith DA,Besas J,Richards JE,Beasley TE,Evansky P,Bushnell PJ

更新日期：2015-12-01 00:00:00

abstract：:Oxidative stress and inflammation are some of the contributing factors for dopaminergic neurodegeneration in Parkinson's disease (PD). Though Valeriana wallichii D.C. is known for its nervine activities its effect against PD is yet to be studied. This is the first report on the antioxidant and anti-inflammatory effect...

journal_title：Neurotoxicology

authors： Sridharan S,Mohankumar K,Jeepipalli SP,Sankaramourthy D,Ronsard L,Subramanian K,Thamilarasan M,Raja K,Chandra VK,Sadras SR

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:The organophosphate insecticide chlorpyrifos (CPF), widely used for agricultural purposes, has been linked to neurodevelopmental deficits. Possible motor effects at low to moderate levels of exposure have not been evaluated. METHODS:Prenatal exposure to CPF was measured in umbilical cord blood in a sample o...

journal_title：Neurotoxicology

authors： Rauh VA,Garcia WE,Whyatt RM,Horton MK,Barr DB,Louis ED

更新日期：2015-12-01 00:00:00

abstract：:Mitochondrial damage and declines in ATP levels have been recently attributed to sertraline. The effects of sertraline on different parameters were investigated in washed platelets from 18 healthy male volunteers, after 24h of drug exposure. Sertraline toxicity was observed only at the highest concentrations, 30 and 1...

journal_title：Neurotoxicology

authors： Rodrigues DO,Bristot IJ,Klamt F,Frizzo ME

更新日期：2015-12-01 00:00:00

abstract：:Many nanoparticles (NPs) have toxic effects on multiple cell lines. This toxicity is assumed to be related to their accumulation within cells. However, the process of internalization of NPs has not yet been fully characterized. In this study, the cellular uptake, accumulation, and localization of titanium dioxide nano...

journal_title：Neurotoxicology

authors： Huerta-García E,Márquez-Ramírez SG,Ramos-Godinez Mdel P,López-Saavedra A,Herrera LA,Parra A,Alfaro-Moreno E,Gómez EO,López-Marure R

更新日期：2015-12-01 00:00:00

abstract：:It is still being debated whether neurogenesis in the subventricular zone (SVZ) is enhanced in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injury in the adult mouse brain. Our previous studies provided evidence that MPTP induces apoptosis of migrating neuroblasts (neural progenitor cells, A cells) ...

journal_title：Neurotoxicology

authors： He XJ,Nakayama H

更新日期：2015-09-01 00:00:00

abstract：:The present study was envisaged to investigate the neuroprotective potential of Allium cepa (A. cepa) in aluminium chloride induced neurotoxicity. Aluminium chloride (50 mg/kg/day) was administered orally in mice supplemented with different doses of A. cepa hydroethanolic extract for a period of 60 days. Various behav...

journal_title：Neurotoxicology

authors： Singh T,Goel RK

更新日期：2015-07-01 00:00:00

abstract：:While hippocampus is a brain region particularly susceptible to the effects of MDMA, the cellular and molecular changes induced by MDMA are still to be fully elucidated, being the dosage regimen, the species and the developmental stage under study great variables. This study compared the effects of one and four days o...

journal_title：Neurotoxicology

authors： García-Cabrerizo R,García-Fuster MJ

更新日期：2015-07-01 00:00:00

abstract：:Phthalates are synthetically derived chemicals used as plasticizers in a variety of common household products. They are not chemically bound to plastic polymers and over time, easily migrate out of these products and into the environment. Experimental investigations evaluating the biological impact of phthalate exposu...

journal_title：Neurotoxicology

authors： Holahan MR,Smith CA

更新日期：2015-05-01 00:00:00

abstract：:The use of pesticides for crop production has grown rapidly in Thailand during the last decade, resulting in significantly greater potential for exposure among children living on farms. Although some previous studies assessed exposures to pesticides in this population, no studies have been conducted to evaluate corres...

journal_title：Neurotoxicology

authors： Fiedler N,Rohitrattana J,Siriwong W,Suttiwan P,Ohman Strickland P,Ryan PB,Rohlman DS,Panuwet P,Barr DB,Robson MG

更新日期：2015-05-01 00:00:00

abstract：:Approximately half of those who survive severe carbon monoxide (CO) poisoning develop delayed neurologic sequelae. Growing evidence supports the crucial role of free radicals in delayed brain injury associated with CO toxicity. Xanthine oxidase (XO) has been reported to play a pivotal role in the generation of reactiv...

journal_title：Neurotoxicology

authors： Dong G,Ren M,Wang X,Jiang H,Yin X,Wang S,Wang X,Feng H

更新日期：2015-05-01 00:00:00

abstract：:Nickel, a known occupational/environmental hazard, may cross the placenta and reach appreciable concentrations in various fetal organs, including the brain. The aim of this study was to investigate whether nickel interferes with the process of neuronal differentiation. Following a 4 week treatment with retinoic acid (...

journal_title：Neurotoxicology

authors： Ceci C,Barbaccia ML,Pistritto G

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Prenatal exposure to p,p'-DDE is associated with impairments in motor development during the first year of life, with no related repercussions on mental or motor development at 12-30 months and with impairments in cognitive areas, but not in perceptual and motor areas at preschool age. However, its associati...

journal_title：Neurotoxicology

authors： Osorio-Valencia E,Torres-Sánchez L,López-Carrillo L,Cebrián ME,Rothenberg SJ,Hernández Chávez Mdel C,Schnaas L

更新日期：2015-03-01 00:00:00

abstract：:Sevoflurane, a commonly used inhaled anesthetic, can induce neuronal apoptosis in the developing rodent brain and correlate with functional neurological impairment later in life. However, the mechanisms underlying these deleterious effects of sevoflurane remain unclear and no effective treatment is currently available...

journal_title：Neurotoxicology

authors： Ji MH,Qiu LL,Yang JJ,Zhang H,Sun XR,Zhu SH,Li WY,Yang JJ

更新日期：2015-01-01 00:00:00

abstract：:The progression of manganism with chronic exposure to airborne manganese (Mn) is not well understood. Here, we further investigate the findings on exposure and neurobehavioral outcomes of workers from a silico- and ferromanganese production plant and non-exposed workers from the same community in 1990 and 2004, using ...

journal_title：Neurotoxicology

authors： Park RM,Bouchard MF,Baldwin M,Bowler R,Mergler D

更新日期：2014-12-01 00:00:00

abstract：:The neurotoxic metals lead (Pb), arsenic (As) and manganese (Mn) are ubiquitous contaminants occurring as mixtures in environmental settings. The three metals may interfere with enzymes of the heme bioshyntetic pathway, leading to excessive porphyrin accumulation, which per se may trigger neurotoxicity. Given the mult...

journal_title：Neurotoxicology

authors： Andrade V,Mateus ML,Batoréu MC,Aschner M,Marreilha dos Santos AP

更新日期：2014-12-01 00:00:00

abstract：:Neurite loss is an early event in neurodegenerative diseases; therefore, the regeneration of the network of neurites constitutes an interesting strategy of treatment for such disorders. Neurotrophic factors play a critical role in neuronal regeneration, but their clinical use is limited by their inability to cross the...

journal_title：Neurotoxicology

authors： dos Santos NA,Martins NM,Silva Rde B,Ferreira RS,Sisti FM,dos Santos AC

更新日期：2014-12-01 00:00:00

abstract：:Nonylphenols (NP) are endocrine-disruptors known to be widely present in our environment. This study evaluated the effects of 4-n-NP on neurobehavioral development and memory capacity after perinatal exposure on the offspring rats. Dams were gavaged with 4-n-NP (0, 50 and 200mg/kg/day) from gestational day 5 to postna...

journal_title：Neurotoxicology

authors： Couderc M,Gandar A,Kamari A,Allain Y,Zalouk-Vergnoux A,Herrenknecht C,Le Bizec B,Mouneyrac C,Poirier L

更新日期：2014-09-01 00:00:00

abstract：:Galantamine, a drug currently approved for the treatment of Alzheimer's disease, has recently emerged as an effective pretreatment against the acute toxicity and delayed cognitive deficits induced by organophosphorus (OP) nerve agents, including soman. Since cognitive deficits can result from impaired glutamatergic tr...

journal_title：Neurotoxicology

authors： Alexandrova EA,Alkondon M,Aracava Y,Pereira EF,Albuquerque EX

更新日期：2014-09-01 00:00:00

abstract：:The contribution of environmental toxicants to the etiology and risk of Parkinson's disease (PD) has been clearly established, with organochlorine insecticides routinely shown to damage the nigrostriatal dopamine pathway. Although PD is generally considered an adult onset disease, it has been postulated that exposure ...

journal_title：Neurotoxicology

authors： Wilson WW,Shapiro LP,Bradner JM,Caudle WM

更新日期：2014-09-01 00:00:00

abstract：:Organophosphate (OP) compounds, including paraoxon (POX), are similar to nerve agents such as sarin. There is a growing concern that OP agents could be weaponized to cause mass civilian causalities. We have developed a rodent survival model of POX toxicity that is being used to evaluate chronic morbidity and to screen...

journal_title：Neurotoxicology

authors： Deshpande LS,Phillips K,Huang B,DeLorenzo RJ

更新日期：2014-09-01 00:00:00

abstract：:Emerging evidences underline the ability of several environmental contaminants to induce an inflammatory response within the central nervous system, named neuroinflammation. This can occur as a consequence of a direct action of the neurotoxicant to the CNS and/or as a response secondary to the activation of the periph...

journal_title：Neurotoxicology

authors： Viviani B,Boraso M,Marchetti N,Marinovich M

更新日期：2014-07-01 00:00:00

abstract：:Lead (Pb) exposure has long been recognized to cause neurological alterations in both adults and children. While most of the studies in adults are related to higher dose exposure, epidemiological studies indicate cognitive decline and neurobehavioral alterations in children associated with lower dose environmental Pb ...

journal_title：Neurotoxicology

authors： Lee J,Freeman JL

更新日期：2014-07-01 00:00:00

abstract：:Methylmercury (MeHg) and prenatal stress (PS) are risk factors for neurotoxicity that may co-occur in human populations. Because they also share biological substrates and can produce common behavioral deficits, this study examined their joint effects on behavioral and neurochemical effects in male and female rats. Dam...

journal_title：Neurotoxicology

authors： Weston HI,Sobolewski ME,Allen JL,Weston D,Conrad K,Pelkowski S,Watson GE,Zareba G,Cory-Slechta DA

更新日期：2014-03-01 00:00:00

abstract：:Lead is one of the major pollutants of environment and is highly toxic to the functioning of central nervous system (CNS). The chronic exposure of this heavy metal is debilitating to the functional behavior of an organism. Studies have shown that acute exposure to Pb can lead to glial activation and secretion of cyto-...

journal_title：Neurotoxicology

authors： Kumawat KL,Kaushik DK,Goswami P,Basu A

更新日期：2014-03-01 00:00:00

abstract：:The present study was designed to examine the protective potential of hydroalcoholic extract of Vitis vinifera in ameliorating the alterations induced by aluminium (Al) on behavioural and neurochemical indices. Al was given orally (100mg/kg b.wt./day) whereas V. vinifera extract was administered through diet (400mg/kg...

journal_title：Neurotoxicology

authors： Lakshmi BV,Sudhakar M,Anisha M

更新日期：2014-03-01 00:00:00

abstract：:Long-term exposure to high manganese (Mn) levels can lead to Parkinson-like neurological disorders. Molecular mechanisms underlying Mn cytotoxicity have been not defined. It is known that Mn induces apoptosis in PC12 cells and that this involves the activation of some signal transduction pathways. Although the role of...

journal_title：Neurotoxicology

authors： Ferrara G,Gambelunghe A,Mozzi R,Marchetti MC,Migliorati G,Muzi G,Buratta S

更新日期：2013-12-01 00:00:00

abstract：:Late Onset Alzheimer Disease (LOAD) constitutes the majority of AD cases (∼90%). Amyloidosis and tau pathology, which are present in AD brains, appear to be sporadic in nature. We have previously shown that infantile lead (Pb) exposure is associated with a change in the expression and regulation of the amyloid precurs...

journal_title：Neurotoxicology

authors： Bihaqi SW,Zawia NH

更新日期：2013-12-01 00:00:00

abstract：:Many soldiers that served in the 1991 Gulf War developed widespread chronic pain. Exposure to insecticides and the nerve gas prophylactic pyridostigmine bromide (PB) was identified as risk factors by the Research Advisory Committee on Gulf War Veterans' Illnesses (GWI). We examined whether a 60 day exposure to neuroto...

journal_title：Neurotoxicology

authors： Nutter TJ,Jiang N,Cooper BY

更新日期：2013-12-01 00:00:00

abstract：:In a previous in vitro study, we demonstrated the protective effects of a new drug, 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride (KHG26377), against glutamate-induced excitotoxicity in cultured glial cells. In this study, we explored the possible mechanisms underlying the neuroprotective and anti-inflammat...

journal_title：Neurotoxicology

authors： Kim EA,Choi J,Han AR,Choi SY,Hahn HG,Cho SW

更新日期：2013-09-01 00:00:00

abstract：:Mining the brain metabolome to understand behavioural disruptions induced in mouse fed Hypochoeris radicata (L.), a neurotoxic plant for horse. C57BL/6J mice orally exposed to 9% H. radicata (HR) are metabolically competent laboratory animals which can be used as model of Australian stringhalt, a neurological horse di...

journal_title：Neurotoxicology

authors： Domange C,Schroeder H,Violle N,Peiffer J,Canlet C,Paris A,Priymenko N

更新日期：2013-09-01 00:00:00

abstract：:ω-Agatoxin-IVA is a well known P/Q-type Ca(2+) channel blocker and has been shown to affect presynaptic Ca(2+) currents as well postsynaptic potentials. P/Q-type voltage gated Ca(2+) channels play a vital role in presynaptic neurotransmitter release and thus play a role in action potential generation. Monitoring spont...

journal_title：Neurotoxicology

authors： Knaack GL,Charkhkar H,Hamilton FW,Peixoto N,O'Shaughnessy TJ,Pancrazio JJ

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Visual functions are known to be sensitive to toxins such as mercury (Hg) and lead (Pb), while omega-3 fatty acids (FA) and selenium (Se) may be protective. In the Tapajós region of the Brazilian Amazon, all of these elements are present in the local diet. OBJECTIVE:Examine how near visual contrast sensitiv...

journal_title：Neurotoxicology

authors： Fillion M,Lemire M,Philibert A,Frenette B,Weiler HA,Deguire JR,Guimarães JR,Larribe F,Barbosa F Jr,Mergler D

更新日期：2013-07-01 00:00:00

abstract：:Okadaic acid (OKA) is one of the main polyether toxins produced by marine microalgae which causes diarrhetic shellfish poisoning. It is a selective and potent inhibitor of serine/threonine phosphatases 1 and 2A induces hyperphosphorylation of tau in vitro and in vivo. The reduced activity of phosphatases like, protein...

journal_title：Neurotoxicology

authors： Kamat PK,Rai S,Nath C

更新日期：2013-07-01 00:00:00

abstract：:The influence of pyrethroid insecticides is thought to be abrogated at mammalian physiological temperatures. Yet there are many reports of transient pain and paresthesia following accidental exposures. Using whole cell patch clamp techniques, we examined the interaction of the pyrethroid insecticide permethrin on skin...

journal_title：Neurotoxicology

authors： Jiang N,Nutter TJ,Cooper BY

更新日期：2013-07-01 00:00:00

abstract：:Vanadium-containing products are manufactured and widely used in the modern industry. Yet the neurobehavioral toxicity due to occupational exposure to vanadium remained elusive. This cross-sectional study was designed to examine the neurotoxic effects of occupational vanadium exposure. A total of 463 vanadium-exposed ...

journal_title：Neurotoxicology

authors： Li H,Zhou D,Zhang Q,Feng C,Zheng W,He K,Lan Y

更新日期：2013-05-01 00:00:00

abstract：:Chlordecone is a persistent organochlorine pesticide that was used in the French West Indies until the early 1990s for banana weevil borer control. Human exposure to this chemical in this area still occurs nowadays due to consumption of contaminated food. Although adverse effects on neurodevelopment, including tremors...

journal_title：Neurotoxicology

authors： Boucher O,Simard MN,Muckle G,Rouget F,Kadhel P,Bataille H,Chajès V,Dallaire R,Monfort C,Thomé JP,Multigner L,Cordier S

更新日期：2013-03-01 00:00:00